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Association study on GNB3 gene polymorphism with essential hypertension in Xinjiang Uygur group

JING Jianying, WANG Dan, WANG Xiaofeng, JIN Jianzhong, JIN Li, JIAO Yi, WEN Hao, LIN Renyong

Frontiers of Medicine 2007, Volume 1, Issue 2,   Pages 230-233 doi: 10.1007/s11684-007-0045-z

Abstract: The relationship between the tenth exon C825T of G-protein β3 subunit (GNB) genetic polymorphism andGNB C825T polymorphism in 354 hypertensive (HT) and 384 normotensive (NT) Uygur subjects.The distributions of GNB C825T genotypes were CC (27.2%), TT (42.9%), and CT (29.9%) in the hypertensiveFurther analysis shows that there is no association between C825T genotypes and age, body mass indexNo evidence was found to suggest an association between GNB C825T polymorphism and hypertension in the

Keywords： case-control     significant difference     reaction-restriction fragment     C825T polymorphism     evidence    

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Association of SIPA1 545 C>T polymorphism with survival in Chinese women with metastatic breast cancer

Renling Pei, Ye Xu, Yan Wei, Tao Ouyang, Jinfeng Li, Tianfeng Wang, Zhaoqing Fan, Tie Fan, Benyao Lin, Yuntao Xie

Frontiers of Medicine 2013, Volume 7, Issue 1,   Pages 138-142 doi: 10.1007/s11684-013-0247-5

Abstract: The purpose of this study was to determine whether SIPA1 545 C>T polymorphism was associatedIn this study, SIPA1 545 C>T polymorphism was detected in 185 metastatic breast cancer patientsSurvival curves for patients with SIPA1 545 C>T polymorphism was compared using the Kaplan-MeierWe found that SIPA1 545 C>T polymorphism was significantly associated with survival in 185Moreover, in multivariate analysis, as compared with the C/C or C/T genotype, the T/T genotype remained

Keywords： SIPA1     polymorphism     metastatic breast cancer     survival    

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Modeling of alkali-silica reaction in concrete: a review

PAN, Y.T. FENG, J.T. WANG, Q.C. SUN, C.H. ZHANG, D.R.J. OWEN

Frontiers of Structural and Civil Engineering 2012, Volume 6, Issue 1,   Pages 1-18 doi: 10.1007/s11709-012-0141-2

Abstract: This paper presents a comprehensive review of modeling of alkali-silica reaction (ASR) in concrete. Such modeling is essential for investigating the chemical expansion mechanism and the subsequent influence on the mechanical aspects of the material. The concept of ASR and the mechanism of expansion are first outlined, and the state-of-the-art of modeling for ASR, the focus of the paper, is then presented in detail. The modeling includes theoretical approaches, meso- and macroscopic models for ASR analysis. The theoretical approaches dealt with the chemical reaction mechanism and were used for predicting pessimum size of aggregate. Mesoscopic models have attempted to explain the mechanism of mechanical deterioration of ASR-affected concrete at material scale. The macroscopic models, chemo-mechanical coupling models, have been generally developed by combining the chemical reaction kinetics with linear or nonlinear mechanical constitutive, and were applied to reproduce and predict the long-term behavior of structures suffering from ASR. Finally, a conclusion and discussion of the modeling are given.

Keywords： alkali-silica reaction (ASR)     modeling     concrete     mesoscopic     macroscopic    

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Novel mutation c.1210-3C>G in with a poly-T tract of 5T affects mRNA splicing in a Chinese patient

Frontiers of Medicine 2022, Volume 16, Issue 1,   Pages 150-155 doi: 10.1007/s11684-021-0846-5

Abstract: The patient is a compound heterozygote of c.2909G>A, p.Gly970Asp in exon 18 and c.1210-3C>G in cis with a poly-T of 5T (T5) sequence, 3 bp upstream in intron 9.plasmid containing c.1210-3C together with T7 sequence produced a normal transcript and partial exon10-skipping-transcript, whereas mutant plasmid containing c.1210-3G in cis with T5 sequence causedOverall, c.1210-3C>G, the newly identified pathogenic mutation in our patient, in combination with T5

Keywords： cystic fibrosis     CFTR     splicing mutation     minigene    

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Spatial and seasonal variations in bacterial communities of the Yellow Sea by T-RFLP analysis

Hongyuan WANG, Xiaolu JIANG, Ya HE, Huashi GUAN

Frontiers of Environmental Science & Engineering 2009, Volume 3, Issue 2,   Pages 194-199 doi: 10.1007/s11783-009-0018-3

Abstract: This was accomplished by using terminal restriction fragment length polymorphism (T-RFLP) analysis ofThe MDA analysis results of T-RFLP profiles coming from I and I both exhibited a significant seasonal

Keywords： terminal restriction fragment length polymorphism (T-RFLP)     bacterial community structure     marine microbial    

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Current molecular biologic techniques for characterizing environmental microbial community

Dawen GAO, Yu TAO

Frontiers of Environmental Science & Engineering 2012, Volume 6, Issue 1,   Pages 82-97 doi: 10.1007/s11783-011-0306-6

Abstract: Microbes are vital to the earth because of their enormous numbers and instinct function maintaining the natural balance. Since the microbiology was applied in environmental science and engineering more than a century ago, researchers desire for more and more information concerning the microbial spatio-temporal variations in almost every fields from contaminated soil to wastewater treatment plant (WWTP). For the past 30 years, molecular biologic techniques explored for environmental microbial community (EMC) have spanned a broad range of approaches to facilitate the researches with the assistance of computer science: faster, more accurate and more sensitive. In this feature article, we outlined several current and emerging molecular biologic techniques applied in detection of EMC, and presented and assessed in detail the application of three promising tools.

Keywords： microbial community     denaturing gradient gel electrophoresis (DGGE)     terminal restriction fragment length polymorphism(T-RFLP)     environmental applications    

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Shear design of high strength concrete prestressed girders

DHONDE,Thomas T. C. HSU,Y. L. MO

Frontiers of Structural and Civil Engineering 2014, Volume 8, Issue 4,   Pages 373-387 doi: 10.1007/s11709-014-0087-7

Abstract: Normal strength prestressed concrete I-girders are commonly used as the primary superstructure components in highway bridges. However, shear design guidelines for high strength PC girders are not available in the current structural codes. Recently, ten 7.62 m (25 feet) long girders made with high strength concrete were designed, cast, and tested at the University of Houston (UH) to study the ultimate shear strength and the shear concrete contribution ( ) as a function of concrete strength ( ). A simple semi-empirical set of equations was developed based on the test results to predict the ultimate shear strength of prestressed concrete I-girders. The UH-developed set of equations is a function of concrete strength ( ), web area ( ), shear span to effective depth ratio ( / ), and percentage of transverse steel ( ). The proposed UH-Method was found to accurately predict the ultimate shear strength of PC girders with concrete strength up to 117 MPa (17000 psi) ensuring satisfactory ductility. The UH-Method was found to be not as overly conservative as the ACI-318 (2011) code provisions, and also not to overestimate the ultimate shear strength of high strength PC girders as the AASHTO LRFD (2010) code provisions. Moreover, the proposed UH-Method was found fairly accurate and not exceedingly conservative in predicting the concrete contribution to shear for concrete strength up to 117 MPa (17000 psi).

Keywords： shear design     high strength concrete     prestressed girders     full-scale tests    

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Thermal degradation characteristics and products obtained after pyrolysis of specific polymers found in Waste Electrical and Electronic Equipment

Evangelia C. Vouvoudi, Aristea T. Rousi, Dimitris S. Achilias

Frontiers of Environmental Science & Engineering 2017, Volume 11, Issue 5, doi: 10.1007/s11783-017-0996-5

Abstract: Modern societies strongly support the recycling practices over simple waste accumulation due to environmental harm caused. In the framework of sustainable recycling of plastics from WEEE, pyrolysis is proposed here as a means of obtaining secondary value-added products. The aim of this study was to investigate the thermal degradation and the products obtained after pyrolysis of specific polymers found in the plastic part of WEEE, using thermogravimetric analysis and a pyrolizer equipped with a GC/MS. Polymers studied include ABS, HIPS, PC and a blend having a composition similar to that appearing in WEEE. It was found that, PC shows greater heat endurance compared to the other polymers, whereas ABS depolymerizes in three-steps. The existence of several polymers in the blend results in synergistic effects which decrease the onset and final temperature of degradation. Moreover, the fragmentation occurred in the pyrolyzer, at certain temperatures, resulted in a great variety of compounds, depending on the polymer type, such as monomers, aromatic products, phenolic compounds and hydrocarbons. The main conclusion from this investigation is that pyrolysis could be an effective method for the sustainable recycling of the plastic part of WEEE resulting in a mixture of chemicals with varying composition but being excellent to be used as fuel retrieved from secondary recycling sources.

Keywords： Pyrolysis     WEEE recycling     ABS     HIPS     PC     Py-GC/MS     TGA    

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Thermal-aware relocation of servers in green data centers

Muhammad Tayyab CHAUDHRY,T. C. LING,S. A. HUSSAIN,Xin-zhu LU

Frontiers of Information Technology & Electronic Engineering 2015, Volume 16, Issue 2,   Pages 119-134 doi: 10.1631/FITEE.1400174

Abstract: Rise in inlet air temperature increases the corresponding outlet air temperature from the server. As an added effect of rise in inlet air temperature, some active servers may start exhaling intensely hot air to form a hotspot. Increase in hot air temperature and occasional hotspots are an added burden on the cooling mechanism and result in energy wastage in data centers. The increase in inlet air temperature may also result in failure of server hardware. Identifying and comparing the thermal sensitivity to inlet air temperature for various servers helps in the thermal-aware arrangement and location switching of servers to minimize the cooling energy wastage. The peak outlet temperature among the relocated servers can be lowered and even be homogenized to reduce the cooling load and chances of hotspots. Based upon mutual comparison of inlet temperature sensitivity of heterogeneous servers, this paper presents a proactive approach for thermal-aware relocation of data center servers. The experimental results show that each relocation operation has a cooling energy saving of as much as 2.1 kW·h and lowers the chances of hotspots by over 77%. Thus, the thermal-aware relocation of servers helps in the establishment of green data centers.

Keywords： Servers     Green data center     Thermal-aware     Relocation    

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A multi-scale model for CO

RUDOLPH, C. T. WEI, Y. QIN

Frontiers of Chemical Science and Engineering 2009, Volume 3, Issue 1,   Pages 20-25 doi: 10.1007/s11705-009-0138-0

Abstract: This paper presents a multi-scale model to simulate the multicomponent gas diffusion and flow in bulk coals for CO sequestration enhanced coalbed methane recovery. The model is developed based on a bi-dispersed structure model by assuming that coal consists of microporous micro-particles, meso/macro-pores and open microfractures. The bi-disperse diffusion theory and the Maxwell-Stefan approach were incorporated in the model, providing an improved simulation of the CH —CO /CH —N counter diffusion dynamics. In the model, the counter diffusion process is numerically coupled with the flow of the mixture gases occurring within macro-pores or fractures in coal so as to account for the interaction between diffusion and flow in gas transport through coals. The model was validated by both experimental data from literature and our CO flush tests, and shows an excellent agreement with the experiments. The results reveal that the gas diffusivities, in particular the micro-pore diffusivities are strongly concentration-dependent.

Keywords： multi-scale model     gas transport     coal     coalbed methane     CO2 sequestration    

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Homoharringtonine synergy with oridonin in treatment of t(8; 21) acute myeloid leukemia

Weina Zhang, Ying Lu, Tao Zhen, Xinjie Chen, Ming Zhang, Ping Liu, Xiangqin Weng, Bing Chen, Yueying Wang

Frontiers of Medicine 2019, Volume 13, Issue 3,   Pages 388-397 doi: 10.1007/s11684-018-0624-1

Abstract: Collaboration of c-KIT mutations with AML1–ETO (AE) has been demonstrated to induce t(8; 21) acute myeloidTargeted therapies designed to eliminate AE and c-KIT oncoproteins may facilitate effective treatmentof t(8; 21) AML.Homoharringtonine (HHT) features activity against tumor cells harboring c-KIT mutations, whereas oridoninOridonin and HHT induced significant downregulation of c-KIT and its downstream signaling pathways and

Keywords： AML1–ETO     c-KIT     homoharringtonine     oridonin     t(8     21) AML     synergistic effect    

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Using a systems modeling approach to improve soil management and soil quality

SMITH, Ben C. T. MACDONALD

Frontiers of Agricultural Science and Engineering 2020, Volume 7, Issue 3,   Pages 289-295 doi: 10.15302/J-FASE-2020337

Abstract:

Soils provide the structural support, water and nutrients for plants in nature and are considered to be the foundation of agriculture production. Improving soil quality and soil health has been advocated as the goal of soil management toward sustainable agricultural intensification. There have been renewed efforts to define and quantify soil quality and soil health but establishing a consensus on the key indicators remains difficult. It is argued that such difficulties are due to the former ways of thinking in soil management which largely focus on soil properties alone. A systems approach that treats soils as a key component of agricultural production systems is promoted. It is argued that soil quality must be quantified in terms of crop productivity and impacts on ecosystems services that are also strongly driven by climate and management interventions. A systems modeling approach captures the interactions among climate, soil, crops and management, and their impacts on system performance, thus helping to quantify the value and quality of soils. Here, three examples are presented to demonstrate this. In this systems context, soil management must be an integral part of systems management practices that also include managing the crops and cropping systems under specific climatic conditions, with cognizance of future climate change.

Keywords： APSIM     available water capacity     nitrogen management     soil functional properties     soil health     soil-plant modeling    

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Design of active orthoses for a robotic gait rehabilitation system

C. VILLA-PARRA,L. BROCHE,D. DELISLE-RODRÍGUEZ,R. SAGARÓ,T. BASTOS,A. FRIZERA-NETO

Frontiers of Mechanical Engineering 2015, Volume 10, Issue 3,   Pages 242-254 doi: 10.1007/s11465-015-0350-1

Abstract:

An active orthosis (AO) is a robotic device that assists both human gait and rehabilitation therapy. This work proposes portable AOs, one for the knee joint and another for the ankle joint. Both AOs will be used to complete a robotic system that improves gait rehabilitation. The requirements for actuator selection, the biomechanical considerations during the AO design, the finite element method, and a control approach based on electroencephalographic and surface electromyographic signals are reviewed. This work contributes to the design of AOs for users with foot drop and knee flexion impairment. However, the potential of the proposed AOs to be part of a robotic gait rehabilitation system that improves the quality of life of stroke survivors requires further investigation.

Keywords： active orthosis     gait rehabilitation     electroencephalography     surface electromyography    

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Towards Cr(VI)-free anodization of aluminum alloys for aerospace adhesive bonding applications: A review

Shoshan T. Abrahami, John M. M. de Kok, Herman Terryn, Johannes M. C. Mol

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 3,   Pages 465-482 doi: 10.1007/s11705-017-1641-3

Abstract: For more than six decades, chromic acid anodizing (CAA) has been the central process in the surface pre-treatment of aluminum for adhesively bonded aircraft structures. Unfortunately, this electrolyte contains hexavalent chromium (Cr(VI)), a compound known for its toxicity and carcinogenic properties. To comply with the new strict international regulations, the Cr(VI)-era will soon have to come to an end. Anodizing aluminum in acid electrolytes produces a self-ordered porous oxide layer. Although different acids can be used to create this type of structure, the excellent adhesion and corrosion resistance that is currently achieved by the complete Cr(VI)-based process is not easily matched. This paper provides a critical overview and appraisal of proposed alternatives to CAA, including combinations of multiple anodizing steps, pre- and post anodizing treatments. The work is presented in terms of the modifications to the oxide properties, such as morphological features (e.g., pore size, barrier layer thickness) and surface chemistry, in order to evaluate the link between fundamental principles of adhesion and bond performance.

Keywords： aluminum     Cr(VI)-free     surface pre-treatments     anodizing     adhesive bonding    

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Community dynamics of ammonia oxidizing bacteria in a full-scale wastewater treatment system with nitrification stability

Xiaohui WANG, Xianghua WEN, Hengjing YAN, Kun DING, Man HU

Frontiers of Environmental Science & Engineering 2011, Volume 5, Issue 1,   Pages 92-98 doi: 10.1007/s11783-010-0254-6

Abstract: community dynamics were investigated using specific PCR followed by terminal restriction fragment length polymorphism(T-RFLP) analysis of the gene.The T-RFLP results indicated that during the period of nitrification stability, the AOB community structure

Keywords： ammonia-oxidizing bacteria (AOB)     community dynamics     terminal restriction fragment length polymorphism(T-RFLP)     nitrification performance    

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Title Author Date Type Operation

Association study on GNB3 gene polymorphism with essential hypertension in Xinjiang Uygur group

JING Jianying, WANG Dan, WANG Xiaofeng, JIN Jianzhong, JIN Li, JIAO Yi, WEN Hao, LIN Renyong

Journal Article

Association of SIPA1 545 C>T polymorphism with survival in Chinese women with metastatic breast cancer

Renling Pei, Ye Xu, Yan Wei, Tao Ouyang, Jinfeng Li, Tianfeng Wang, Zhaoqing Fan, Tie Fan, Benyao Lin, Yuntao Xie

Journal Article

Modeling of alkali-silica reaction in concrete: a review

PAN, Y.T. FENG, J.T. WANG, Q.C. SUN, C.H. ZHANG, D.R.J. OWEN

Journal Article

Novel mutation c.1210-3C>G in with a poly-T tract of 5T affects mRNA splicing in a Chinese patient

Journal Article

Spatial and seasonal variations in bacterial communities of the Yellow Sea by T-RFLP analysis

Hongyuan WANG, Xiaolu JIANG, Ya HE, Huashi GUAN

Journal Article

Current molecular biologic techniques for characterizing environmental microbial community

Dawen GAO, Yu TAO

Journal Article

Shear design of high strength concrete prestressed girders

DHONDE,Thomas T. C. HSU,Y. L. MO

Journal Article

Thermal degradation characteristics and products obtained after pyrolysis of specific polymers found in Waste Electrical and Electronic Equipment

Evangelia C. Vouvoudi, Aristea T. Rousi, Dimitris S. Achilias

Journal Article

Thermal-aware relocation of servers in green data centers

Muhammad Tayyab CHAUDHRY,T. C. LING,S. A. HUSSAIN,Xin-zhu LU

Journal Article

A multi-scale model for CO

RUDOLPH, C. T. WEI, Y. QIN

Journal Article

Homoharringtonine synergy with oridonin in treatment of t(8; 21) acute myeloid leukemia

Weina Zhang, Ying Lu, Tao Zhen, Xinjie Chen, Ming Zhang, Ping Liu, Xiangqin Weng, Bing Chen, Yueying Wang

Journal Article

Using a systems modeling approach to improve soil management and soil quality

SMITH, Ben C. T. MACDONALD

Journal Article

Design of active orthoses for a robotic gait rehabilitation system

C. VILLA-PARRA,L. BROCHE,D. DELISLE-RODRÍGUEZ,R. SAGARÓ,T. BASTOS,A. FRIZERA-NETO

Journal Article

Towards Cr(VI)-free anodization of aluminum alloys for aerospace adhesive bonding applications: A review

Shoshan T. Abrahami, John M. M. de Kok, Herman Terryn, Johannes M. C. Mol

Journal Article

Community dynamics of ammonia oxidizing bacteria in a full-scale wastewater treatment system with nitrification stability

Xiaohui WANG, Xianghua WEN, Hengjing YAN, Kun DING, Man HU

Journal Article